ETHANOLIC EXTRACT OF Monodora myristica SEED ATTENUATED INFLAMMATORY RESPONSES IN TYPE II DIABETES-INDUCED COMPLICATIONS IN WISTER RATS

Abstract

Diabetes mellitus is a chronic metabolic disease characterized by persistent hyperglycemia resulting in various complications including retinopathy, nephropathy, erectile dysfunction, and hypertension. Due to the high cost and potential adverse effects of existing treatment options for diabetes, which pose a challenge for individuals with middle and low incomes, there has been a need to explore alternative solutions from phytotherapy. As a result, the effectiveness of ethanolic extract of Monodora myristica seed (EEMMS) and selenium nanoparticles (SeNp) was investigated for the management of diabetes. A total of 40 male rats (156.25 ± 5.6g) were randomly divided into seven groups. Group A received 0.5 ml of distilled water while the rats in groups B, C, D, E, F, G, H were intraperitoneally induced into diabetes with streptozotocin. The diabetic rats were orallyadministered 0.5ml of distilled water, 0.5 ml of metformin, EEMMS (25, 50, and 100) and SeNp (10 and 20) mg/kg bw respectively, once daily for 14 day. Biochemical assessments were carried out. The result revealed that the EEMMS and SeNp administration significantly reduced the STZ-induced tissue necrotic factors (TNF-α), the 50 mg of the EEMMS is the most potent and should be further investigated for its possibility of being a drug candidate for the treatment of diabetes.