CARDIO-PROTECTIVES EFFECT OF AQUEOUS ETHANOLIC EXTRACT OF CARICA PAPAYA LEAVES ON ISOPROTERENOL INDUCED CARDIOTOXICITY IN FEMALE WISTAR RATS

Abstract

The prevalence of cardiovascular diseases has been rising globally, causing high death rate only after cancer. Myocardial Infarction is a CDVs disease condition of the heart tissue resulting from the obstruction of blood supply to the heart muscles. Medicinal plants present alternative therapeutic, cheaper and less side effects over synthetic drugs in the treatment and prevention of MI. The present study analyzed the phytochemical constituents of hydroethanolic extract of Carica Papaya leaves extract (CPE) and assessed the efficacy of CPE in protecting the heart from Isoproterenol (ISP) induced MI in female rats. Through GC-MS analysis of the CPE and integrated library search, nineteen bioactive compounds; alkaloids, phenolics, flavonoids and also, amino acids were identified. The effects of treatment with 0.5 ml of various concentrations (100, 200, and 400 mg/kg) of CPE on body weight changes, serum marker enzymes such as serum protein, aspartate transaminase (AST), and alanine transaminase (ALT) were studied during the 15 days experimental period. ISP-induced rats showed no significant (P>0.05) effect on the body weight but increased significantly (P<0.05) AST and ALT. Pretreatment with doses of CPE significantly (P<0.05) extenuated the elevated levels of AST as well as ALT while restoring towards normal the activities of CAT and SOD. This work contributes to the conclusion that, when administered to animals with MI, CPE exhibit cardio-protective activity effects. Keywords: Myocardial infarction, Carica papaya, Isoproterenol, Phytochemicals, Cardiac biomarkers.