THE POTENTIAL OF HYDROETHANOLIC EXTRACT OF Carica papaya LEAVES ON ISOPRENALINE INDUCED CARDIOMYOPATHY IN FEMALE WISTAR RATS
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2024
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Abstract
The prevalence of cardiovascular diseases (CDVs) has been rising globally, causing high death rate only after cancer. Cardiomyopathy is a CDVs disease condition of the heart tissue resulting from the pathological disorder marked by the dysfunction of the myocardium. Medicinal plants present alternative therapeutic, cheaper and less side effects over synthetic drugs in the treatment and prevention of cardiomyopathy. The present study analyzed the phytochemical constituents of hydroethanolic extract of Carica Papaya leaves extract (CPE) and assessed the efficacy of CPE in protecting the heart from Isoproterenol (ISP) induced cardiomyopathy in female rats. Through GC-MS analysis of the CPE and integrated library search, nineteen bioactive compounds; alkaloids, phenolics, flavonoids and also, amino acids were identified. The effects of treatment with 0.5 ml of various concentrations (100, 200, and 400 mg/kg) of CPE on body weight changes, serum marker enzymes such as creatinine kinase (CK) and troponin I were studied. ISP-induced rats showed no significant (P>0.05) effect on the body weight but increased significantly (P>0.05) Troponin I and creatinine kinase levels. Pretreatment with doses of CPE significantly (P>0.05) extenuated the elevated levels of troponin I and CK. This work contributes to the conclusion that, when administered to animals with cardiomyopathy, CPE exhibit cardio-protective activity effects.
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The prevalence of cardiovascular diseases (CDVs) has been rising globally, causing high death rate only after cancer. Cardiomyopathy is a CDVs disease condition of the heart tissue resulting from the pathological disorder marked by the dysfunction of the myocardium. Medicinal plants present alternative therapeutic, cheaper and less side effects over synthetic drugs in the treatment and prevention of cardiomyopathy. The present study analyzed the phytochemical constituents of hydroethanolic extract of Carica Papaya leaves extract (CPE) and assessed the efficacy of CPE in protecting the heart from Isoproterenol (ISP) induced cardiomyopathy in female rats. Through GC-MS analysis of the CPE and integrated library search, nineteen bioactive compounds, alkaloids, phenolics, flavonoids and also, amino acids were identified. The effects of treatment with 0.5 ml of various concentrations (100, 200, and 400 mg/kg) of CPE on body weight changes, serum marker enzymes such as creatinine kinase (CK) and troponin I were studied. ISP-induced rats showed no significant (P>0.05) effect on the body weight but increased significantly (P>0.05) Troponin I and creatinine kinase levels. Pretreatment with doses of CPE significantly (P>0.05) extenuated the elevated levels of troponin I and CK. This work contributes to the conclusion that, when administered to animals with cardiomyopathy, CPE exhibit cardio-protective activity effects.