Biochemistry

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    ETHANOLIC EXTRACT OF Monodora myristica SEED ATTENUATED DIABETES-RELATED NEPHROPATIC COMPLICATION
    (2023) BISIRIYU, ZAINAB ABIODUN
    Diabetes mellitus (DM) is a long-term metabolic condition characterized by high levels of blood glucose. This can occur due to insufficient secretion of the hormone insulin or damage to the pancreatic β cells, which are responsible for producing insulin. It is associated with both acute and chronic complications. There is no effective cure for diabetes and the available treatments are known to produce serious adverse effects, drug resistance, not easily affordable, and not readily available, hence the search for traditional or alternative medicinal plants which are safe and effective for the management of diabetes. Monodora myristica and Selenium nanoparticle has been reported to possess various therapeutic properties, including potential anti-diabetic effects. The objectives of this study were to: (i) Induce diabetes in rats using streptozotocin; (ii) synthesize selenium nanoparticle using ethanolic extract of Monodora myristica seed; (iii) evaluate the safety of the ethanolic extract of Monodora myristica seed using biological parameters of kidney function. A total of forty (40) male Wistar rats with an average weight of 156.18g were used for this study. The animals were grouped into eight groups of five animals each with group A which is the positive control (non-diabetic rats) group receiving 0.5 ml of distilled water and the diabetic rats {induced by intraperitoneal administration of 35 mg/kg body weight (b.wt) of streptozotocin} in groups B, C, D, E, F, G, H orally administered distilled water, metformin (reference antidiabetic drug), 25, 50, 100, 10 and 20 mg/kg b.wt of EEMMS and selenium nanoparticle respectively, once daily for 14 days. Biochemical analysis such as kidney function indexes was determined. Data were statistically analyzed by one-way analysis of variance (ANOVA) followed by Dunnett’s multiple comparisons at P < 0.05. The findings in this study revealed that the administration of ethanolic extract of Monodora myristica seed (EEMMS) and selenium nanoparticle (SeNp) led to a significant decrease in the Urea and Uric acid level of the diabetic rats when compared to the diabetic rats receiving treated water.